SPAIN - A team of researchers from the National Research Council (CSIC) has determined the structure of the complex molecular machine that the influenza virus uses to replicate and express their genetic material.
The results, which are published in Science Express, the online edition of the journalScience, opens the way to unravel some of the crucial steps in the life cycle of these viruses that infect birds endemic also to humans and other mammals.
Researchers have revealed ribonucleoproteins organisation, protein complexes formed by each RNA (ribonucleic acid) associated with the viral polymerase and nucleoprotein, multiple copies of which bind to RNA like beads on a necklace.
"This complex structure actually functions as a molecular machine capable of transcribing the genetic message of self-replication of the virus and the infected cell in order to generate new progeny virus to infect other cells," explains Juan Ortin, CSIC researcher at the National Center for Biotechnology.
Researchers have revealed ribonucleoproteins organisation, protein complexes formed by each RNA (ribonucleic acid) associated with the viral polymerase and nucleoprotein, multiple copies of which bind to RNA like beads on a necklace.
"This complex structure actually functions as a molecular machine capable of transcribing the genetic message of self-replication of the virus and the infected cell in order to generate new progeny virus to infect other cells," explains Juan Ortin, CSIC researcher at the National Center for Biotechnology.
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